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The 2004 Mercedes E320 can hold up to 8.5 quarts of engine oil, including what is used up by the filter. Some Mercedes models with oil coolers may need slightly more oil, typically around .5 to 1 quart. It is important to use a fully synthetic 5W-40 engine oil for best results. Mercedes suggests changing the oil every 7,500 to 10,000 miles for optimal performance.
The 2004 Mercedes E320 requires 8 liters of engine oil for optimal performance.