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To adjust the clock on your 2000 Ford F-250, hold down the "CLK" button and then use the Seek buttons to change the hour and the Tune buttons to adjust the minutes. Release the "CLK" button once you've set the correct time. If you notice issues with the radio, such as the time not being maintained or presets being lost, consider having your battery checked as a failing battery can cause unexpected electronic issues in your vehicle.
Press and hold the "clk" button until "clock set" appears on the screen. Once that's shown, adjust the hour by pressing the "seek" arrows, followed by setting the minutes using the "tune" arrows.